Southwest Church of Christ has a heart for mission work, partially supporting Lawson Mayo in Australia, Walsenburg (Colorado) Church of Christ, Robert Reid in Abilene, Texas, Ed Wharton in Lubbock, Texas, Jerry Lawlis in Amarillo, Texas, and World Christian Broadcasting.
And if anyone gives even a cup of cold water to one of these little ones because he is my disciple, I tell you the truth, he will certainly not lose his reward.
- AIM Program - Young people have served and are serving through Adventures in Missions (AIM) program.
- South America - Southwest has served and is sponsering churches for the Kent Marcum family in Quito, Ecuador since January 1988. The North Quito congregation is the home of the Quito School of Bibilical Studies.
- Mexico - In October 1994, Southwest Church of Christ assumed the oversight of Casa de la Ezperanza (House of Hope), a children's home serving over 50 children in Anahuac, Mexico. Joe Valenuela was director from April 1995 through May 1998. Gilbert Sanchez has served as director from June 1998 to the present time.